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There is very little to nothing published on the topic of the interaction of birth control and anabolic androgenic steroids so it is hard to say how they truly interact. There have been some recent studies that have suggested that progesterone may inhibit androgen-dependent androgen production in the developing ovaries. In fact, many studies have shown that progesterone increases androgen production and decreases androgen-dependent estrogen production. Although I have my own theories on how this might occur, it might make sense to explain my thoughts in the case of women that produce the highest levels of estrogen in their bodies as this causes the greatest amount of hyperprolactinemia. In the case of women that produce the lowest levels of estrogen, there should be very little effect from progesterone on androgen production. Unfortunately, a lot of the current literature on the effects of progesterone on androgen production is very anecdotal and often just speculation based on the patient's history alone. So, does progesterone inhibit testosterone production or is it merely the reverse? I cannot answer this one without going into more detail on how hormones are produced and how their interactions with one another work to produce their individual effects. There are also some other hormones, including cortisol, that are known to influence anabolic androgenic steroid steroid (AAS) production during puberty and early adulthood. They are called androgen receptor modulators because they affect the function of the androgen receptor. Progesterone, androgens, prolactin or follicle stimulating hormone (FSH) are all hormones that increase androgen production. So, all of these hormones work by increasing androgen production. Thus, progesterone might inhibit androgen production, androgens might inhibit progesterone production, and these interactions are very mysterious. There are several reports of how progesterone levels are elevated post-progestins use, as well as some early reports of post-op progesterone use in which progesterone was demonstrated to inhibit androgen production. It is also conceivable that progesterone itself inhibits the actions of all of these androgens, but this is largely speculation at this time. So, what about progestin replacement during puberty or early adulthood? This is of course highly controversial and some studies don't support it and the evidence may be lacking. However, many studies show a positive effect of progestin for breast reduction, muscle mass and bone density, and for decreasing androgen receptor and/or aromatase activity. Therefore, we should probably be more comfortable with progesterone supplementation during puberty than for normal breasts. It's also been noted that progester Related Article: